Preparation of a reservoir type levonorgestrel delivery system using high molecular weight poly L-lactide

preparation of a reservoir type levonorgestrel delivery system using high molecular weight poly l-lactide

implantable contraceptive is likely to be a promising new option for fertility control, as we have entered the twenty-first century and the world’s population grows by one billion people in a single decade. the main objective of this study was to develop a subdermal implant for levonorgestrol (a synthetic progestin from 19-norandrostanes) using a high molecular weight biodegradable polymer , i....

Poly(D, L-lactide-co-glycolide)/Poly(ethylenimine) Blend Matrix System for pH Sensitive Drug Delivery

Poly(d,l-lactide-co-glycolide) (PLGA) and poly(ethylenimine) (PEI) were blended and found to form a homogeneous pH sensitive matrix for drug release. Differential scanning calorimetry (DSC) studies of the PLGA/PEI blends showed a single glass transition temperature at all compositions. Fourier transform infrared spectroscopy (FTIR) demonstrated that the PLGA carbonyl peak at 1760 cm 1 shifted t...

Preparation of Ultra High Molecular Weight Polyethylene Using Ziegler-Natta Catalyst System: Optimization of Parameters by Response Surface Methodology

Electrospinning of Poly(L-lactide-co-D, L-lactide)

Electrospinning method was used to fabricate poly(L-lactide-co-D,L-lactide) (PLDLA) nanofiber non-woven membranes. The structure and morphology of the electrospun membranes were investigated by a scanning electron microscope (JEOL) after a gold coating. The diameter of the electrospun fiber was measured by Adobe Photoshop 5.0 software from the SEM pictures. SEM images showed that the fiber diam...

Synthesis and properties of a novel biodegradable poly(ester amine) copolymer based on poly(L-lactide) and low molecular weight polyethylenimine for gene delivery

BACKGROUND Gene therapy is a promising approach to the treatment of a wide range of diseases. The development of efficient and adequate gene delivery systems could be one of the most important factors. Polyethyleneimine, a cationic polymer, is one of the most successful and widely used vectors for nonviral transfection in vitro and in vivo. METHODS A novel biodegradable poly(ester amine) copo...